New York Center for Structural Genomics


NYSGRC ID	Priority	stage	Locus Tag	NCBI GI	Common Name	Sequence Length	Project	Homolog PDB ID	Homolog Sequence Identity	Target Organism	Request Person
000001 (show subtarget assignments)	1	purified	APE_0163.1	118430913	hypothetical protein APE_0163.1 [Aeropyr...	442	BIO:FDA (FDA-Approved Drug Targets)	1KY8	26.3%	Aeropyrum pernix

000002 (show subtarget assignments)	1	cloned	APE_0260.1	118430958	dihydroorotate dehydrogenase 1B [Aeropyr...	306	BIO:FDA (FDA-Approved Drug Targets)	1EP1	33.7%	Aeropyrum pernix

000003 (show subtarget assignments)	1	soluble	APE_0412	14600688	hypothetical protein APE_0412 [Aeropyrum...	362	BIO:FDA (FDA-Approved Drug Targets)	3MAF	25.4%	Aeropyrum pernix

000004 (show subtarget assignments)	1	cloned	APE_0507.1	118431082	proteasome beta subunit precursor [Aerop...	203	BIO:FDA (FDA-Approved Drug Targets)	1J2Q	36.9%	Aeropyrum pernix

000005 (show subtarget assignments)	1	cloned	APE_0521.1	118431089	proteasome beta subunit precursor [Aerop...	219	BIO:FDA (FDA-Approved Drug Targets)	3H4P	43.4%	Aeropyrum pernix

000006 (show subtarget assignments)	1	cloned	APE_0569	14600809	3-phosphoshikimate 1-carboxyvinyltransfe...	427	BIO:FDA (FDA-Approved Drug Targets)	3RMT	32.4%	Aeropyrum pernix

000007 (show subtarget assignments)	1	cloned	APE_0807.1	118431207	delta-1-pyrroline-5-carboxylate dehydrog...	540	BIO:FDA (FDA-Approved Drug Targets)	3RJL	34%	Aeropyrum pernix

000008 (show subtarget assignments)	1	cloned	APE_1336.1	14602204	putative phytoene dehydrogenase [Aeropyr...	549	BIO:FDA (FDA-Approved Drug Targets)			Aeropyrum pernix

000009 (show subtarget assignments)	1	cloned	APE_1507.1	118431484	inosine-5'-monophosphate dehydrogenase [...	433	BIO:FDA (FDA-Approved Drug Targets)	2CU0	38.9%	Aeropyrum pernix

000010 (show subtarget assignments)	1	purified	APE_1786.1	118431591	NADP-dependent glyceraldehyde-3-phosphat...	510	BIO:FDA (FDA-Approved Drug Targets)	1KY8	53.9%	Aeropyrum pernix

000011 (show subtarget assignments)	1	cloned	APE_1869	14601684	3-hydroxy-3-methylglutaryl-coenzyme A re...	421	BIO:FDA (FDA-Approved Drug Targets)	2Q1L	42.4%	Aeropyrum pernix

000012 (show subtarget assignments)	1	cloned	APE_2348	14602012	orotidine 5'-phosphate decarboxylase [Ae...	244	BIO:FDA (FDA-Approved Drug Targets)	2CZ5	34%	Aeropyrum pernix

000013 (show subtarget assignments)	1	cloned	MJ_0252	15668427	hypothetical protein MJ_0252 [Methanocal...	234	BIO:FDA (FDA-Approved Drug Targets)	1DV7	46.6%	Methanocaldococcus jannaschii

000014 (show subtarget assignments)	1	cloned	MJ_0502	15668679	3-phosphoshikimate 1-carboxyvinyltransfe...	429	BIO:FDA (FDA-Approved Drug Targets)	1G6S	35.2%	Methanocaldococcus jannaschii

000015 (show subtarget assignments)	1	soluble	MJ_0654	15668835	dihydroorotate dehydrogenase 1B [Methano...	306	BIO:FDA (FDA-Approved Drug Targets)	1EP1	37.6%	Methanocaldococcus jannaschii

000016 (show subtarget assignments)	1	crystallized	MJ_0705	15668887	3-hydroxy-3-methylglutaryl coenzyme A re...	405	BIO:FDA (FDA-Approved Drug Targets)	1DQ8	43.7%	Methanocaldococcus jannaschii

000017 (show subtarget assignments)	1	in_pdb 3PQA 3RHD	MJ_1411	15669601	glyceraldehyde-3-phosphate dehydrogenase...	463	BIO:FDA (FDA-Approved Drug Targets)	3PQA	100%	Methanocaldococcus jannaschii

000018 (show subtarget assignments)	1	cloned	MTH1202	15679213	proteasome, beta subunit [Methanothermob...	210	BIO:FDA (FDA-Approved Drug Targets)	1J2Q	51.4%	Methanothermobacter thermautotrophicus

000019 (show subtarget assignments)	1	cloned	MTH766	15678791	3-phosphoshikimate 1-carboxyvinyltransfe...	419	BIO:FDA (FDA-Approved Drug Targets)	3NVS	35.3%	Methanothermobacter thermautotrophicus

000020 (show subtarget assignments)	1	cloned	MTH978	15678996	NADP-dependent glyceraldehyde-3-phosphat...	455	BIO:FDA (FDA-Approved Drug Targets)	3PQA	40%	Methanothermobacter thermautotrophicus

000021 (show subtarget assignments)	1	cloned	MTH208	15678236	DNA-dependent DNA polymerase family B pr...	223	BIO:FDA (FDA-Approved Drug Targets)	1WN7	47.1%	Methanothermobacter thermautotrophicus

000022 (show subtarget assignments)	1	cloned	MTH1807	15679795	phytoene dehydrogenase [Methanothermobac...	514	BIO:FDA (FDA-Approved Drug Targets)	3KA7	18.9%	Methanothermobacter thermautotrophicus

000023 (show subtarget assignments)	1	cloned	MTH774	15678799	thymidylate synthase [Methanothermobacte...	227	BIO:FDA (FDA-Approved Drug Targets)	1BP0	23.8%	Methanothermobacter thermautotrophicus

000024 (show subtarget assignments)	1	cloned	MTH562	15678590	3-hydroxy-3-methylglutaryl CoA reductase...	397	BIO:FDA (FDA-Approved Drug Targets)	1DQ8	43.3%	Methanothermobacter thermautotrophicus

000025 (show subtarget assignments)	1	cloned	MTH1808	15679796	phytoene synthase [Methanothermobacter t...	299	BIO:FDA (FDA-Approved Drug Targets)	2ZCO	19.1%	Methanothermobacter thermautotrophicus

000026 (show subtarget assignments)	1	cloned	MTH1116	15679127	L-tyrosine decarboxylase [Methanothermob...	363	BIO:FDA (FDA-Approved Drug Targets)	3F9T	45.3%	Methanothermobacter thermautotrophicus

000027 (show subtarget assignments)	1	cloned	MTH142	15678170	inosine-5'-monophosphate dehydrogenase [...	484	BIO:FDA (FDA-Approved Drug Targets)	2CU0	58%	Methanothermobacter thermautotrophicus

000028 (show subtarget assignments)	1	soluble	MTH652	15678679	ribonucleotide reductase, large subunit ...	703	BIO:FDA (FDA-Approved Drug Targets)	1XJE	33.9%	Methanothermobacter thermautotrophicus

000029 (show subtarget assignments)	1	cloned	MTH758	15678783	S-D-lactoylglutathione methylglyoxal lya...	116	BIO:FDA (FDA-Approved Drug Targets)	3G12	30.2%	Methanothermobacter thermautotrophicus

000030 (show subtarget assignments)	1	cloned	MTH1213	15679224	dihydroorotate dehydrogenase 1B [Methano...	303	BIO:FDA (FDA-Approved Drug Targets)	1EP1	40.9%	Methanothermobacter thermautotrophicus

000031 (show subtarget assignments)	1	cloned	AF0745	11498351	dihydroorotase dehydrogenase (pyrD) [Arc...	299	BIO:FDA (FDA-Approved Drug Targets)	1EP1	33.1%	Archaeoglobus fulgidus

000032 (show subtarget assignments)	1	cloned	AF0929	11498534	hypothetical protein AF0929 [Archaeoglob...	241	BIO:FDA (FDA-Approved Drug Targets)	2CZ5	39.8%	Archaeoglobus fulgidus

000033 (show subtarget assignments)	1	cloned	AF1738	11499327	hypothetical protein AF1738 [Archaeoglob...	404	BIO:FDA (FDA-Approved Drug Targets)	1I8T	19.1%	Archaeoglobus fulgidus

000034 (show subtarget assignments)	1	cloned	AF2004	11499586	L-tyrosine decarboxylase [Archaeoglobus ...	367	BIO:FDA (FDA-Approved Drug Targets)	3F9T	44.3%	Archaeoglobus fulgidus

000035 (show subtarget assignments)	1	soluble	PH0425	14590342	hypothetical protein PH0425 [Pyrococcus ...	440	BIO:FDA (FDA-Approved Drug Targets)	3UTE	28.8%	Pyrococcus horikoshii

000036 (show subtarget assignments)	1	cloned	PH1026	14590865	membrane dipeptidase [Pyrococcus horikos...	320	BIO:FDA (FDA-Approved Drug Targets)	3NEH	30.9%	Pyrococcus horikoshii

000037 (show subtarget assignments)	1	purified	PH1402	14591201	proteasome beta subunit precursor [Pyroc...	207	BIO:FDA (FDA-Approved Drug Targets)	3H4P	45.9%	Pyrococcus horikoshii

000038 (show subtarget assignments)	1	cloned	PH1516	14591298	dihydroorotate dehydrogenase 1B [Pyrococ...	303	BIO:FDA (FDA-Approved Drug Targets)	1GT8	36.9%	Pyrococcus horikoshii

000039 (show subtarget assignments)	1	soluble	1	16081246	orotidine 5'-phosphate decarboxylase [Th...	215	BIO:FDA (FDA-Approved Drug Targets)	2CZ5	40.9%	Thermoplasma acidophilum

000040 (show subtarget assignments)	1	purified	NC_002578.1\|:81342-81953	16081255	phosphoribosylglycinamide formyltransfer...	203	BIO:FDA (FDA-Approved Drug Targets)	2YWR	37.7%	Thermoplasma acidophilum

000041 (show subtarget assignments)	1	cloned	1	16081368	inosine 5'-monophosphate dehydrogenase [...	485	BIO:FDA (FDA-Approved Drug Targets)	2CU0	57.1%	Thermoplasma acidophilum

000042 (show subtarget assignments)	1	soluble	1	16081424	3-phosphoshikimate 1-carboxyvinyltransfe...	410	BIO:FDA (FDA-Approved Drug Targets)	2GG4	26.6%	Thermoplasma acidophilum

000043 (show subtarget assignments)	1	cloned	1	16081529	dihydroorotate dehydrogenase 1B [Thermop...	300	BIO:FDA (FDA-Approved Drug Targets)	1EP1	35.3%	Thermoplasma acidophilum

000044 (show subtarget assignments)	1	purified	1	16081561	piperideine-6-carboxilic acid dehydrogen...	512	BIO:FDA (FDA-Approved Drug Targets)	2JG7	48%	Thermoplasma acidophilum

000045 (show subtarget assignments)	1	soluble	1	16081701	aldehyde dehydrogenase related protein [...	515	BIO:FDA (FDA-Approved Drug Targets)	3QAN	37.1%	Thermoplasma acidophilum

000046 (show subtarget assignments)	1	soluble	1	16081867	aldehyde dehydrogenase [Thermoplasma aci...	493	BIO:FDA (FDA-Approved Drug Targets)	2HG2	37.3%	Thermoplasma acidophilum

000047 (show subtarget assignments)	1	cloned	TVN0028	13540859	orotidine 5'-phosphate decarboxylase [Th...	226	BIO:FDA (FDA-Approved Drug Targets)	1X1Z	34.9%	Thermoplasma volcanium

000048 (show subtarget assignments)	1	cloned	TVN0171	13541002	folate-dependent phosphoribosylglycinami...	200	BIO:FDA (FDA-Approved Drug Targets)	2YWR	35.3%	Thermoplasma volcanium

000049 (show subtarget assignments)	1	cloned	TVN0397	13541228	NAD-dependent aldehyde dehydrogenase [Th...	498	BIO:FDA (FDA-Approved Drug Targets)	1BXS	38%	Thermoplasma volcanium

000050 (show subtarget assignments)	1	cloned	TVN1021	13541852	NAD-dependent aldehyde dehydrogenase [Th...	493	BIO:FDA (FDA-Approved Drug Targets)	2OPX	38.5%	Thermoplasma volcanium

000051 (show subtarget assignments)	1	purified	TVN1054	13541885	NAD-dependent aldehyde dehydrogenase [Th...	514	BIO:FDA (FDA-Approved Drug Targets)	2JG7	47.9%	Thermoplasma volcanium

000052 (show subtarget assignments)	1	cloned	TVN1170	13542001	dihydroorotate dehydrogenase 1B [Thermop...	301	BIO:FDA (FDA-Approved Drug Targets)	1EP1	36.5%	Thermoplasma volcanium

000053 (show subtarget assignments)	1	soluble	TVN1283	13542114	NAD-dependent aldehyde dehydrogenase [Th...	436	BIO:FDA (FDA-Approved Drug Targets)	3EFV	37.5%	Thermoplasma volcanium

000054 (show subtarget assignments)	1	cloned	TVN1319	13542150	3-phosphoshikimate 1-carboxyvinyltransfe...	410	BIO:FDA (FDA-Approved Drug Targets)	2BJB	26.7%	Thermoplasma volcanium

000055 (show subtarget assignments)	1	cloned	TVN1375	13542206	inosine 5'-monophosphate dehydrogenase [...	485	BIO:FDA (FDA-Approved Drug Targets)	2CU0	55.8%	Thermoplasma volcanium

000056 (show subtarget assignments)	1	soluble	SSO0278	15897221	proteasome subunit [Sulfolobus solfatari...	196	BIO:FDA (FDA-Approved Drug Targets)	3H4P	40.8%	Sulfolobus solfataricus

000057 (show subtarget assignments)	1	soluble	SSO0309	15897251	3-phosphoshikimate 1-carboxyvinyltransfe...	414	BIO:FDA (FDA-Approved Drug Targets)	1RF4	27.4%	Sulfolobus solfataricus

000058 (show subtarget assignments)	1	purified	SSO0531	15897456	3 hydroxy 3 methylglutaryl coenzyme a re...	409	BIO:FDA (FDA-Approved Drug Targets)	1DQ8	41.9%	Sulfolobus solfataricus

000059 (show subtarget assignments)	1	cloned	SSO0616	15897532	orotidine 5'-phosphate decarboxylase (OM...	222	BIO:FDA (FDA-Approved Drug Targets)	2CZ5	34.2%	Sulfolobus solfataricus

000060 (show subtarget assignments)	1	cloned	SSO0766	15897668	proteasome subunit [Sulfolobus solfatari...	225	BIO:FDA (FDA-Approved Drug Targets)	3H4P	38.7%	Sulfolobus solfataricus

000061 (show subtarget assignments)	1	purified	SSO1218	15898070	methylmalonate-semialdehyde dehydrogenas...	492	BIO:FDA (FDA-Approved Drug Targets)	1T90	46%	Sulfolobus solfataricus

000062 (show subtarget assignments)	1	purified	SSO1629	15898448	glyceraldehyde-3-phosphate dehydrogenase...	470	BIO:FDA (FDA-Approved Drug Targets)	3PQA	41.9%	Sulfolobus solfataricus

000063 (show subtarget assignments)	1	cloned	SSO2095	15898879	maltooligosyl trehalose synthase [Sulfol...	732	BIO:FDA (FDA-Approved Drug Targets)	3HJE	52.6%	Sulfolobus solfataricus

000064 (show subtarget assignments)	1	soluble	SSO2426	15899175	lactoylglutathione lyase (glyoxalase I),...	142	BIO:FDA (FDA-Approved Drug Targets)	3OA4	41.6%	Sulfolobus solfataricus

000065 (show subtarget assignments)	1	cloned	SSO2942	15899651	carbon monoxide dehydrogenase, large cha...	684	BIO:FDA (FDA-Approved Drug Targets)	1N5W	30.6%	Sulfolobus solfataricus

000066 (show subtarget assignments)	1	purified	SSO3117	15899825	aldehyde dehydrogenase [Sulfolobus solfa...	478	BIO:FDA (FDA-Approved Drug Targets)	1BXS	39.6%	Sulfolobus solfataricus

000067 (show subtarget assignments)	1	soluble	SSO3194	15899897	glyceraldehyde-3-phosphate dehydrogenase...	509	BIO:FDA (FDA-Approved Drug Targets)	1UXV	54.2%	Sulfolobus solfataricus

000068 (show subtarget assignments)	1	cloned	PF0159	18976531	multicatalytic endopeptidase complex bet...	196	BIO:FDA (FDA-Approved Drug Targets)	3H4P	45.4%	Pyrococcus furiosus

000069 (show subtarget assignments)	1	cloned	PF0755	18977127	non-phosphorylating glyceraldehyde-3-pho...	506	BIO:FDA (FDA-Approved Drug Targets)	1UXN	43.3%	Pyrococcus furiosus

000070 (show subtarget assignments)	1	cloned	PF1404	18977776	proteasome, subunit beta (multicatalytic...	206	BIO:FDA (FDA-Approved Drug Targets)	3H4P	46.6%	Pyrococcus furiosus

000071 (show subtarget assignments)	1	cloned	PF1699	18978071	3-phosphoshikimate 1-carboxyvinyltransfe...	440	BIO:FDA (FDA-Approved Drug Targets)	3RMT	30.7%	Pyrococcus furiosus

000072 (show subtarget assignments)	1	soluble	MM_0048	21226150	aldehyde dehydrogenase [Methanosarcina m...	492	BIO:FDA (FDA-Approved Drug Targets)	1BXS	40.8%	Methanosarcina mazei

000073 (show subtarget assignments)	1	purified	MM_0232	21226334	hypothetical protein MM_0232 [Methanosar...	123	BIO:FDA (FDA-Approved Drug Targets)	2R6U	36.5%	Methanosarcina mazei

000074 (show subtarget assignments)	1	purified	MM_0335	21226437	3-hydroxy-3-methylglutaryl-coenzyme A re...	418	BIO:FDA (FDA-Approved Drug Targets)	1DQ8	42.4%	Methanosarcina mazei

000075 (show subtarget assignments)	1	cloned	MM_0836	21226938	hypothetical protein MM_0836 [Methanosar...	443	BIO:FDA (FDA-Approved Drug Targets)	3KA7	24.8%	Methanosarcina mazei

000076 (show subtarget assignments)	1	cloned	MM_0838	21226940	succinate-semialdehyde dehydrogenase [NA...	479	BIO:FDA (FDA-Approved Drug Targets)	1BXS	42.4%	Methanosarcina mazei

000077 (show subtarget assignments)	1	cloned	MM_1237	21227339	thymidylate synthase [Methanosarcina maz...	217	BIO:FDA (FDA-Approved Drug Targets)	1BP0	24.9%	Methanosarcina mazei

000078 (show subtarget assignments)	1	purified	MM_1238	21227340	3-phosphoshikimate 1-carboxyvinyltransfe...	430	BIO:FDA (FDA-Approved Drug Targets)	3NVS	34.7%	Methanosarcina mazei

000079 (show subtarget assignments)	1	cloned	MM_1675	21227777	hypothetical protein MM_1675 [Methanosar...	225	BIO:FDA (FDA-Approved Drug Targets)	3R79	38.2%	Methanosarcina mazei

000080 (show subtarget assignments)	1	cloned	MM_1745	161485673	dihydroorotate dehydrogenase 1B [Methano...	301	BIO:FDA (FDA-Approved Drug Targets)	1EP1	35.2%	Methanosarcina mazei

000081 (show subtarget assignments)	1	soluble	MM_2341	21228443	succinate-semialdehyde dehydrogenase [NA...	454	BIO:FDA (FDA-Approved Drug Targets)	3EFV	41.6%	Methanosarcina mazei

000082 (show subtarget assignments)	1	cloned	MM_2830	21228932	ribonucleoside-diphosphate [Methanosarci...	553	BIO:FDA (FDA-Approved Drug Targets)	1XJE	39.1%	Methanosarcina mazei

000083 (show subtarget assignments)	1	purified	MM_3029	21229131	lactoylglutathione lyase [Methanosarcina...	130	BIO:FDA (FDA-Approved Drug Targets)	2P25	31.6%	Methanosarcina mazei

000084 (show subtarget assignments)	1	in_pdb 3R6A	MM_3218	21229320	hypothetical protein MM_3218 [Methanosar...	120	BIO:FDA (FDA-Approved Drug Targets)	3R6A	100%	Methanosarcina mazei

000085 (show subtarget assignments)	1	cloned	MM_3331	21229433	hypothetical protein MM_3331 [Methanosar...	484	BIO:FDA (FDA-Approved Drug Targets)	1SEZ	10.5%	Methanosarcina mazei

000086 (show subtarget assignments)	1	purified	pNG7153	55376716	inosine-5'-monophosphate dehydrogenase [...	369	BIO:FDA (FDA-Approved Drug Targets)	3KHJ	40.1%	Haloarcula marismortui

000087 (show subtarget assignments)	1	soluble	pNG7359	55376907	dihydrofolate reductase [Haloarcula mari...	167	BIO:FDA (FDA-Approved Drug Targets)	3QL0	42%	Haloarcula marismortui

000088 (show subtarget assignments)	1	cloned	rrnAC0073	55377009	cytochrome P450 [Haloarcula marismortui ...	445	BIO:FDA (FDA-Approved Drug Targets)	3DBG	30.8%	Haloarcula marismortui

000089 (show subtarget assignments)	1	soluble	rrnAC0201	55377118	aldehyde dehydrogenase [Haloarcula maris...	508	BIO:FDA (FDA-Approved Drug Targets)	2WME	42.5%	Haloarcula marismortui

000090 (show subtarget assignments)	1	soluble	rrnAC0321	55377227	phytoene dehydrogenase [Haloarcula maris...	495	BIO:FDA (FDA-Approved Drug Targets)	3LOV	5.4%	Haloarcula marismortui

000091 (show subtarget assignments)	1	cloned	rrnAC1072	55377890	cytochrome P450 [Haloarcula marismortui ...	441	BIO:FDA (FDA-Approved Drug Targets)	3DBG	29%	Haloarcula marismortui

000092 (show subtarget assignments)	1	cloned	rrnAC1257	55378055	caffeoyl-CoA O-methyltransferase [Haloar...	222	BIO:FDA (FDA-Approved Drug Targets)	2GPY	27%	Haloarcula marismortui

000093 (show subtarget assignments)	1	cloned	rrnAC1902	55378633	phytoene dehydrogenase [Haloarcula maris...	507	BIO:FDA (FDA-Approved Drug Targets)	2IVD	18%	Haloarcula marismortui

000094 (show subtarget assignments)	1	cloned	rrnAC1966	55378690	lactoylglutathione lyase [Haloarcula mar...	126	BIO:FDA (FDA-Approved Drug Targets)	1F9Z	30.9%	Haloarcula marismortui

000095 (show subtarget assignments)	1	cloned	rrnAC1970	55378693	hypothetical protein rrnAC1970 [Haloarcu...	376	BIO:FDA (FDA-Approved Drug Targets)	1GA0	24.7%	Haloarcula marismortui

000097 (show subtarget assignments)	1	soluble	rrnAC2473	55379135	aldehyde dehydrogenase [Haloarcula maris...	522	BIO:FDA (FDA-Approved Drug Targets)	3RJL	32.3%	Haloarcula marismortui

000098 (show subtarget assignments)	1	cloned	rrnAC2969	55379558	dihydroorotate dehydrogenase 2 [Haloarcu...	350	BIO:FDA (FDA-Approved Drug Targets)	1UUM	42%	Haloarcula marismortui

000099 (show subtarget assignments)	1	cloned	rrnAC3312	55379859	cytochrome P450 [Haloarcula marismortui ...	458	BIO:FDA (FDA-Approved Drug Targets)	3QI8	28.4%	Haloarcula marismortui

000100 (show subtarget assignments)	1	cloned	rrnAC3351	55379896	hypothetical protein rrnAC3351 [Haloarcu...	453	BIO:FDA (FDA-Approved Drug Targets)	2C72	22.1%	Haloarcula marismortui

000101 (show subtarget assignments)	1	cloned	rrnAC3412	55379948	3-hydroxy-3-methylglutaryl-coenzyme A re...	405	BIO:FDA (FDA-Approved Drug Targets)	1DQ8	40.9%	Haloarcula marismortui

000001
(show subtarget assignments)

1

purified

APE_0163.1

118430913

hypothetical protein APE_0163.1 [Aeropyr...

442

BIO:FDA (FDA-Approved Drug Targets)

1KY8

26.3%

Aeropyrum pernix

000002
(show subtarget assignments)

1

cloned

APE_0260.1

118430958

dihydroorotate dehydrogenase 1B [Aeropyr...

306

BIO:FDA (FDA-Approved Drug Targets)

1EP1

33.7%

Aeropyrum pernix

000003
(show subtarget assignments)

1

soluble

APE_0412

14600688

hypothetical protein APE_0412 [Aeropyrum...

362

BIO:FDA (FDA-Approved Drug Targets)

3MAF

25.4%

Aeropyrum pernix

000004
(show subtarget assignments)

1

cloned

APE_0507.1

118431082

proteasome beta subunit precursor [Aerop...

203

BIO:FDA (FDA-Approved Drug Targets)

1J2Q

36.9%

Aeropyrum pernix

000005
(show subtarget assignments)

1

cloned

APE_0521.1

118431089

proteasome beta subunit precursor [Aerop...

219

BIO:FDA (FDA-Approved Drug Targets)

3H4P

43.4%

Aeropyrum pernix

000006
(show subtarget assignments)

1

cloned

APE_0569

14600809

3-phosphoshikimate 1-carboxyvinyltransfe...

427

BIO:FDA (FDA-Approved Drug Targets)

3RMT

32.4%

Aeropyrum pernix

000007
(show subtarget assignments)

1

cloned

APE_0807.1

118431207

delta-1-pyrroline-5-carboxylate dehydrog...

540

BIO:FDA (FDA-Approved Drug Targets)

3RJL

34%

Aeropyrum pernix

000008
(show subtarget assignments)

1

cloned

APE_1336.1

14602204

putative phytoene dehydrogenase [Aeropyr...

549

BIO:FDA (FDA-Approved Drug Targets)

Aeropyrum pernix

000009
(show subtarget assignments)

1

cloned

APE_1507.1

118431484

inosine-5'-monophosphate dehydrogenase [...

433

BIO:FDA (FDA-Approved Drug Targets)

2CU0

38.9%

Aeropyrum pernix

000010
(show subtarget assignments)

1

purified

APE_1786.1

118431591

NADP-dependent glyceraldehyde-3-phosphat...

510

BIO:FDA (FDA-Approved Drug Targets)

1KY8

53.9%

Aeropyrum pernix

000011
(show subtarget assignments)

1

cloned

APE_1869

14601684

3-hydroxy-3-methylglutaryl-coenzyme A re...

421

BIO:FDA (FDA-Approved Drug Targets)

2Q1L

42.4%

Aeropyrum pernix

000012
(show subtarget assignments)

1

cloned

APE_2348

14602012

orotidine 5'-phosphate decarboxylase [Ae...

244

BIO:FDA (FDA-Approved Drug Targets)

2CZ5

34%

Aeropyrum pernix

000013
(show subtarget assignments)

1

cloned

MJ_0252

15668427

hypothetical protein MJ_0252 [Methanocal...

234

BIO:FDA (FDA-Approved Drug Targets)

1DV7

46.6%

Methanocaldococcus jannaschii

000014
(show subtarget assignments)

1

cloned

MJ_0502

15668679

3-phosphoshikimate 1-carboxyvinyltransfe...

429

BIO:FDA (FDA-Approved Drug Targets)

1G6S

35.2%

Methanocaldococcus jannaschii

000015
(show subtarget assignments)

1

soluble

MJ_0654

15668835

dihydroorotate dehydrogenase 1B [Methano...

306

BIO:FDA (FDA-Approved Drug Targets)

1EP1

37.6%

Methanocaldococcus jannaschii

000016
(show subtarget assignments)

1

crystallized

MJ_0705

15668887

3-hydroxy-3-methylglutaryl coenzyme A re...

405

BIO:FDA (FDA-Approved Drug Targets)

1DQ8

43.7%

Methanocaldococcus jannaschii

000017
(show subtarget assignments)

1

in_pdb
3PQA
3RHD

MJ_1411

15669601

glyceraldehyde-3-phosphate dehydrogenase...

463

BIO:FDA (FDA-Approved Drug Targets)

3PQA

100%

Methanocaldococcus jannaschii

000018
(show subtarget assignments)

1

cloned

MTH1202

15679213

proteasome, beta subunit [Methanothermob...

210

BIO:FDA (FDA-Approved Drug Targets)

1J2Q

51.4%

Methanothermobacter thermautotrophicus

000019
(show subtarget assignments)

1

cloned

MTH766

15678791

3-phosphoshikimate 1-carboxyvinyltransfe...

419

BIO:FDA (FDA-Approved Drug Targets)

3NVS

35.3%

Methanothermobacter thermautotrophicus

000020
(show subtarget assignments)

1

cloned

MTH978

15678996

NADP-dependent glyceraldehyde-3-phosphat...

455

BIO:FDA (FDA-Approved Drug Targets)

3PQA

40%

Methanothermobacter thermautotrophicus

000021
(show subtarget assignments)

1

cloned

MTH208

15678236

DNA-dependent DNA polymerase family B pr...

223

BIO:FDA (FDA-Approved Drug Targets)

1WN7

47.1%

Methanothermobacter thermautotrophicus

000022
(show subtarget assignments)

1

cloned

MTH1807

15679795

phytoene dehydrogenase [Methanothermobac...

514

BIO:FDA (FDA-Approved Drug Targets)

3KA7

18.9%

Methanothermobacter thermautotrophicus

000023
(show subtarget assignments)

1

cloned

MTH774

15678799

thymidylate synthase [Methanothermobacte...

227

BIO:FDA (FDA-Approved Drug Targets)

1BP0

23.8%

Methanothermobacter thermautotrophicus

000024
(show subtarget assignments)

1

cloned

MTH562

15678590

3-hydroxy-3-methylglutaryl CoA reductase...

397

BIO:FDA (FDA-Approved Drug Targets)

1DQ8

43.3%

Methanothermobacter thermautotrophicus

000025
(show subtarget assignments)

1

cloned

MTH1808

15679796

phytoene synthase [Methanothermobacter t...

299

BIO:FDA (FDA-Approved Drug Targets)

2ZCO

19.1%

Methanothermobacter thermautotrophicus

000026
(show subtarget assignments)

1

cloned

MTH1116

15679127

L-tyrosine decarboxylase [Methanothermob...

363

BIO:FDA (FDA-Approved Drug Targets)

3F9T

45.3%

Methanothermobacter thermautotrophicus

000027
(show subtarget assignments)

1

cloned

MTH142

15678170

inosine-5'-monophosphate dehydrogenase [...

484

BIO:FDA (FDA-Approved Drug Targets)

2CU0

58%

Methanothermobacter thermautotrophicus

000028
(show subtarget assignments)

1

soluble

MTH652

15678679

ribonucleotide reductase, large subunit ...

703

BIO:FDA (FDA-Approved Drug Targets)

1XJE

33.9%

Methanothermobacter thermautotrophicus

000029
(show subtarget assignments)

1

cloned

MTH758

15678783

S-D-lactoylglutathione methylglyoxal lya...

116

BIO:FDA (FDA-Approved Drug Targets)

3G12

30.2%

Methanothermobacter thermautotrophicus

000030
(show subtarget assignments)

1

cloned

MTH1213

15679224

dihydroorotate dehydrogenase 1B [Methano...

303

BIO:FDA (FDA-Approved Drug Targets)

1EP1

40.9%

Methanothermobacter thermautotrophicus

000031
(show subtarget assignments)

1

cloned

AF0745

11498351

dihydroorotase dehydrogenase (pyrD) [Arc...

299

BIO:FDA (FDA-Approved Drug Targets)

1EP1

33.1%

Archaeoglobus fulgidus

000032
(show subtarget assignments)

1

cloned

AF0929

11498534

hypothetical protein AF0929 [Archaeoglob...

241

BIO:FDA (FDA-Approved Drug Targets)

2CZ5

39.8%

Archaeoglobus fulgidus

000033
(show subtarget assignments)

1

cloned

AF1738

11499327

hypothetical protein AF1738 [Archaeoglob...

404

BIO:FDA (FDA-Approved Drug Targets)

1I8T

19.1%

Archaeoglobus fulgidus

000034
(show subtarget assignments)

1

cloned

AF2004

11499586

L-tyrosine decarboxylase [Archaeoglobus ...

367

BIO:FDA (FDA-Approved Drug Targets)

3F9T

44.3%

Archaeoglobus fulgidus

000035
(show subtarget assignments)

1

soluble

PH0425

14590342

hypothetical protein PH0425 [Pyrococcus ...

440

BIO:FDA (FDA-Approved Drug Targets)

3UTE

28.8%

Pyrococcus horikoshii

000036
(show subtarget assignments)

1

cloned

PH1026

14590865

membrane dipeptidase [Pyrococcus horikos...

320

BIO:FDA (FDA-Approved Drug Targets)

3NEH

30.9%

Pyrococcus horikoshii

000037
(show subtarget assignments)

1

purified

PH1402

14591201

proteasome beta subunit precursor [Pyroc...

207

BIO:FDA (FDA-Approved Drug Targets)

3H4P

45.9%

Pyrococcus horikoshii

000038
(show subtarget assignments)

1

cloned

PH1516

14591298

dihydroorotate dehydrogenase 1B [Pyrococ...

303

BIO:FDA (FDA-Approved Drug Targets)

1GT8

36.9%

Pyrococcus horikoshii

000039
(show subtarget assignments)

1

soluble

1

16081246

orotidine 5'-phosphate decarboxylase [Th...

215

BIO:FDA (FDA-Approved Drug Targets)

2CZ5

40.9%

Thermoplasma acidophilum

000040
(show subtarget assignments)

1

purified

NC_002578.1|:81342-81953

16081255

phosphoribosylglycinamide formyltransfer...

203

BIO:FDA (FDA-Approved Drug Targets)

2YWR

37.7%

Thermoplasma acidophilum

000041
(show subtarget assignments)

1

cloned

1

16081368

inosine 5'-monophosphate dehydrogenase [...

485

BIO:FDA (FDA-Approved Drug Targets)

2CU0

57.1%

Thermoplasma acidophilum

000042
(show subtarget assignments)

1

soluble

1

16081424

3-phosphoshikimate 1-carboxyvinyltransfe...

410

BIO:FDA (FDA-Approved Drug Targets)

2GG4

26.6%

Thermoplasma acidophilum

000043
(show subtarget assignments)

1

cloned

1

16081529

dihydroorotate dehydrogenase 1B [Thermop...

300

BIO:FDA (FDA-Approved Drug Targets)

1EP1

35.3%

Thermoplasma acidophilum

000044
(show subtarget assignments)

1

purified

1

16081561

piperideine-6-carboxilic acid dehydrogen...

512

BIO:FDA (FDA-Approved Drug Targets)

2JG7

48%

Thermoplasma acidophilum

000045
(show subtarget assignments)

1

soluble

1

16081701

aldehyde dehydrogenase related protein [...

515

BIO:FDA (FDA-Approved Drug Targets)

3QAN

37.1%

Thermoplasma acidophilum

000046
(show subtarget assignments)

1

soluble

1

16081867

aldehyde dehydrogenase [Thermoplasma aci...

493

BIO:FDA (FDA-Approved Drug Targets)

2HG2

37.3%

Thermoplasma acidophilum

000047
(show subtarget assignments)

1

cloned

TVN0028

13540859

orotidine 5'-phosphate decarboxylase [Th...

226

BIO:FDA (FDA-Approved Drug Targets)

1X1Z

34.9%

Thermoplasma volcanium

000048
(show subtarget assignments)

1

cloned

TVN0171

13541002

folate-dependent phosphoribosylglycinami...

200

BIO:FDA (FDA-Approved Drug Targets)

2YWR

35.3%

Thermoplasma volcanium

000049
(show subtarget assignments)

1

cloned

TVN0397

13541228

NAD-dependent aldehyde dehydrogenase [Th...

498

BIO:FDA (FDA-Approved Drug Targets)

1BXS

38%

Thermoplasma volcanium

000050
(show subtarget assignments)

1

cloned

TVN1021

13541852

NAD-dependent aldehyde dehydrogenase [Th...

493

BIO:FDA (FDA-Approved Drug Targets)

2OPX

38.5%

Thermoplasma volcanium

000051
(show subtarget assignments)

1

purified

TVN1054

13541885

NAD-dependent aldehyde dehydrogenase [Th...

514

BIO:FDA (FDA-Approved Drug Targets)

2JG7

47.9%

Thermoplasma volcanium

000052
(show subtarget assignments)

1

cloned

TVN1170

13542001

dihydroorotate dehydrogenase 1B [Thermop...

301

BIO:FDA (FDA-Approved Drug Targets)

1EP1

36.5%

Thermoplasma volcanium

000053
(show subtarget assignments)

1

soluble

TVN1283

13542114

NAD-dependent aldehyde dehydrogenase [Th...

436

BIO:FDA (FDA-Approved Drug Targets)

3EFV

37.5%

Thermoplasma volcanium

000054
(show subtarget assignments)

1

cloned

TVN1319

13542150

3-phosphoshikimate 1-carboxyvinyltransfe...

410

BIO:FDA (FDA-Approved Drug Targets)

2BJB

26.7%

Thermoplasma volcanium

000055
(show subtarget assignments)

1

cloned

TVN1375

13542206

inosine 5'-monophosphate dehydrogenase [...

485

BIO:FDA (FDA-Approved Drug Targets)

2CU0

55.8%

Thermoplasma volcanium

000056
(show subtarget assignments)

1

soluble

SSO0278

15897221

proteasome subunit [Sulfolobus solfatari...

196

BIO:FDA (FDA-Approved Drug Targets)

3H4P

40.8%

Sulfolobus solfataricus

000057
(show subtarget assignments)

1

soluble

SSO0309

15897251

3-phosphoshikimate 1-carboxyvinyltransfe...

414

BIO:FDA (FDA-Approved Drug Targets)

1RF4

27.4%

Sulfolobus solfataricus

000058
(show subtarget assignments)

1

purified

SSO0531

15897456

3 hydroxy 3 methylglutaryl coenzyme a re...

409

BIO:FDA (FDA-Approved Drug Targets)

1DQ8

41.9%

Sulfolobus solfataricus

000059
(show subtarget assignments)

1

cloned

SSO0616

15897532

orotidine 5'-phosphate decarboxylase (OM...

222

BIO:FDA (FDA-Approved Drug Targets)

2CZ5

34.2%

Sulfolobus solfataricus

000060
(show subtarget assignments)

1

cloned

SSO0766

15897668

proteasome subunit [Sulfolobus solfatari...

225

BIO:FDA (FDA-Approved Drug Targets)

3H4P

38.7%

Sulfolobus solfataricus

000061
(show subtarget assignments)

1

purified

SSO1218

15898070

methylmalonate-semialdehyde dehydrogenas...

492

BIO:FDA (FDA-Approved Drug Targets)

1T90

46%

Sulfolobus solfataricus

000062
(show subtarget assignments)

1

purified

SSO1629

15898448

glyceraldehyde-3-phosphate dehydrogenase...

470

BIO:FDA (FDA-Approved Drug Targets)

3PQA

41.9%

Sulfolobus solfataricus

000063
(show subtarget assignments)

1

cloned

SSO2095

15898879

maltooligosyl trehalose synthase [Sulfol...

732

BIO:FDA (FDA-Approved Drug Targets)

3HJE

52.6%

Sulfolobus solfataricus

000064
(show subtarget assignments)

1

soluble

SSO2426

15899175

lactoylglutathione lyase (glyoxalase I),...

142

BIO:FDA (FDA-Approved Drug Targets)

3OA4

41.6%

Sulfolobus solfataricus

000065
(show subtarget assignments)

1

cloned

SSO2942

15899651

carbon monoxide dehydrogenase, large cha...

684

BIO:FDA (FDA-Approved Drug Targets)

1N5W

30.6%

Sulfolobus solfataricus

000066
(show subtarget assignments)

1

purified

SSO3117

15899825

aldehyde dehydrogenase [Sulfolobus solfa...

478

BIO:FDA (FDA-Approved Drug Targets)

1BXS

39.6%

Sulfolobus solfataricus

000067
(show subtarget assignments)

1

soluble

SSO3194

15899897

glyceraldehyde-3-phosphate dehydrogenase...

509

BIO:FDA (FDA-Approved Drug Targets)

1UXV

54.2%

Sulfolobus solfataricus

000068
(show subtarget assignments)

1

cloned

PF0159

18976531

multicatalytic endopeptidase complex bet...

196

BIO:FDA (FDA-Approved Drug Targets)

3H4P

45.4%

Pyrococcus furiosus

000069
(show subtarget assignments)

1

cloned

PF0755

18977127

non-phosphorylating glyceraldehyde-3-pho...

506

BIO:FDA (FDA-Approved Drug Targets)

1UXN

43.3%

Pyrococcus furiosus

000070
(show subtarget assignments)

1

cloned

PF1404

18977776

proteasome, subunit beta (multicatalytic...

206

BIO:FDA (FDA-Approved Drug Targets)

3H4P

46.6%

Pyrococcus furiosus

000071
(show subtarget assignments)

1

cloned

PF1699

18978071

3-phosphoshikimate 1-carboxyvinyltransfe...

440

BIO:FDA (FDA-Approved Drug Targets)

3RMT

30.7%

Pyrococcus furiosus

000072
(show subtarget assignments)

1

soluble

MM_0048

21226150

aldehyde dehydrogenase [Methanosarcina m...

492

BIO:FDA (FDA-Approved Drug Targets)

1BXS

40.8%

Methanosarcina mazei

000073
(show subtarget assignments)

1

purified

MM_0232

21226334

hypothetical protein MM_0232 [Methanosar...

123

BIO:FDA (FDA-Approved Drug Targets)

2R6U

36.5%

Methanosarcina mazei

000074
(show subtarget assignments)

1

purified

MM_0335

21226437

3-hydroxy-3-methylglutaryl-coenzyme A re...

418

BIO:FDA (FDA-Approved Drug Targets)

1DQ8

42.4%

Methanosarcina mazei

000075
(show subtarget assignments)

1

cloned

MM_0836

21226938

hypothetical protein MM_0836 [Methanosar...

443

BIO:FDA (FDA-Approved Drug Targets)

3KA7

24.8%

Methanosarcina mazei

000076
(show subtarget assignments)

1

cloned

MM_0838

21226940

succinate-semialdehyde dehydrogenase [NA...

479

BIO:FDA (FDA-Approved Drug Targets)

1BXS

42.4%

Methanosarcina mazei

000077
(show subtarget assignments)

1

cloned

MM_1237

21227339

thymidylate synthase [Methanosarcina maz...

217

BIO:FDA (FDA-Approved Drug Targets)

1BP0

24.9%

Methanosarcina mazei

000078
(show subtarget assignments)

1

purified

MM_1238

21227340

3-phosphoshikimate 1-carboxyvinyltransfe...

430

BIO:FDA (FDA-Approved Drug Targets)

3NVS

34.7%

Methanosarcina mazei

000079
(show subtarget assignments)

1

cloned

MM_1675

21227777

hypothetical protein MM_1675 [Methanosar...

225

BIO:FDA (FDA-Approved Drug Targets)

3R79

38.2%

Methanosarcina mazei

000080
(show subtarget assignments)

1

cloned

MM_1745

161485673

dihydroorotate dehydrogenase 1B [Methano...

301

BIO:FDA (FDA-Approved Drug Targets)

1EP1

35.2%

Methanosarcina mazei

000081
(show subtarget assignments)

1

soluble

MM_2341

21228443

succinate-semialdehyde dehydrogenase [NA...

454

BIO:FDA (FDA-Approved Drug Targets)

3EFV

41.6%

Methanosarcina mazei

000082
(show subtarget assignments)

1

cloned

MM_2830

21228932

ribonucleoside-diphosphate [Methanosarci...

553

BIO:FDA (FDA-Approved Drug Targets)

1XJE

39.1%

Methanosarcina mazei

000083
(show subtarget assignments)

1

purified

MM_3029

21229131

lactoylglutathione lyase [Methanosarcina...

130

BIO:FDA (FDA-Approved Drug Targets)

2P25

31.6%

Methanosarcina mazei

000084
(show subtarget assignments)

1

in_pdb
3R6A

MM_3218

21229320

hypothetical protein MM_3218 [Methanosar...

120

BIO:FDA (FDA-Approved Drug Targets)

3R6A

100%

Methanosarcina mazei

000085
(show subtarget assignments)

1

cloned

MM_3331

21229433

hypothetical protein MM_3331 [Methanosar...

484

BIO:FDA (FDA-Approved Drug Targets)

1SEZ

10.5%

Methanosarcina mazei

000086
(show subtarget assignments)

1

purified

pNG7153

55376716

inosine-5'-monophosphate dehydrogenase [...

369

BIO:FDA (FDA-Approved Drug Targets)

3KHJ

40.1%

Haloarcula marismortui

000087
(show subtarget assignments)

1

soluble

pNG7359

55376907

dihydrofolate reductase [Haloarcula mari...

167

BIO:FDA (FDA-Approved Drug Targets)

3QL0

42%

Haloarcula marismortui

000088
(show subtarget assignments)

1

cloned

rrnAC0073

55377009

cytochrome P450 [Haloarcula marismortui ...

445

BIO:FDA (FDA-Approved Drug Targets)

3DBG

30.8%

Haloarcula marismortui

000089
(show subtarget assignments)

1

soluble

rrnAC0201

55377118

aldehyde dehydrogenase [Haloarcula maris...

508

BIO:FDA (FDA-Approved Drug Targets)

2WME

42.5%

Haloarcula marismortui

000090
(show subtarget assignments)

1

soluble

rrnAC0321

55377227

phytoene dehydrogenase [Haloarcula maris...

495

BIO:FDA (FDA-Approved Drug Targets)

3LOV

5.4%

Haloarcula marismortui

000091
(show subtarget assignments)

1

cloned

rrnAC1072

55377890

cytochrome P450 [Haloarcula marismortui ...

441

BIO:FDA (FDA-Approved Drug Targets)

3DBG

29%

Haloarcula marismortui

000092
(show subtarget assignments)

1

cloned

rrnAC1257

55378055

caffeoyl-CoA O-methyltransferase [Haloar...

222

BIO:FDA (FDA-Approved Drug Targets)

2GPY

27%

Haloarcula marismortui

000093
(show subtarget assignments)

1

cloned

rrnAC1902

55378633

phytoene dehydrogenase [Haloarcula maris...

507

BIO:FDA (FDA-Approved Drug Targets)

2IVD

18%

Haloarcula marismortui

000094
(show subtarget assignments)

1

cloned

rrnAC1966

55378690

lactoylglutathione lyase [Haloarcula mar...

126

BIO:FDA (FDA-Approved Drug Targets)

1F9Z

30.9%

Haloarcula marismortui

000095
(show subtarget assignments)

1

cloned

rrnAC1970

55378693

hypothetical protein rrnAC1970 [Haloarcu...

376

BIO:FDA (FDA-Approved Drug Targets)

1GA0

24.7%

Haloarcula marismortui

000097
(show subtarget assignments)

1

soluble

rrnAC2473

55379135

aldehyde dehydrogenase [Haloarcula maris...

522

BIO:FDA (FDA-Approved Drug Targets)

3RJL

32.3%

Haloarcula marismortui

000098
(show subtarget assignments)

1

cloned

rrnAC2969

55379558

dihydroorotate dehydrogenase 2 [Haloarcu...

350

BIO:FDA (FDA-Approved Drug Targets)

1UUM

42%

Haloarcula marismortui

000099
(show subtarget assignments)

1

cloned

rrnAC3312

55379859

cytochrome P450 [Haloarcula marismortui ...

458

BIO:FDA (FDA-Approved Drug Targets)

3QI8

28.4%

Haloarcula marismortui

000100
(show subtarget assignments)

1

cloned

rrnAC3351

55379896

hypothetical protein rrnAC3351 [Haloarcu...

453

BIO:FDA (FDA-Approved Drug Targets)

2C72

22.1%

Haloarcula marismortui

000101
(show subtarget assignments)

1

cloned

rrnAC3412

55379948

3-hydroxy-3-methylglutaryl-coenzyme A re...

405

BIO:FDA (FDA-Approved Drug Targets)

1DQ8

40.9%

Haloarcula marismortui